{"id":11065,"date":"2022-03-17T23:34:50","date_gmt":"2022-03-17T23:34:50","guid":{"rendered":"https:\/\/insilicall.com\/?p=11065"},"modified":"2023-02-22T17:55:45","modified_gmt":"2023-02-22T17:55:45","slug":"organo-azidos-nova-impureza-medicamentos","status":"publish","type":"post","link":"https:\/\/insilicall.com\/organo-azidos-nova-impureza-medicamentos\/","title":{"rendered":"Organo Azidos, uma nova impureza em medicamentos."},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"11065\" class=\"elementor elementor-11065\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-1b1b6c9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1b1b6c9\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-77d368c\" data-id=\"77d368c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-267a113 elementor-widget elementor-widget-text-editor\" data-id=\"267a113\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p><span style=\"font-weight: 400\">Nitrosaminas n\u00e3o os \u00fanicos contaminantes de IFAs, desde 2021 a classe dos <\/span><b>azidos <\/b>(organo azidos) <span style=\"font-weight: 400\">tem sido investigada por ag\u00eancias internacionais, que notificaram a presen\u00e7a desta impureza no ativo \u2018losartana pot\u00e1ssica\u2019, bem como em outros f\u00e1rmacos pertencentes \u00e0 classe das sartanas.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f73c53a elementor-widget elementor-widget-text-editor\" data-id=\"f73c53a\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Confira tudo sobre nitrosaminas clicando <strong><span style=\"color: #003366\"><a style=\"color: #003366\" href=\"https:\/\/insilicall.com\/tag\/nitrosaminas\/\">aqui<\/a><\/span><\/strong>!<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e5513e4 elementor-widget elementor-widget-text-editor\" data-id=\"e5513e4\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Dentre os \u00f3rg\u00e3os internacionais de alta relev\u00e2ncia temos a \u201cDiretoria Europeia para a Qualidade dos Medicamentos e Cuidados de Sa\u00fade\u201d (do ingl\u00eas, <\/span><b>EDQM<\/b><span style=\"font-weight: 400\">), ela faz parte do Conselho da Europa que tem as suas origens e estatutos na \u201cConven\u00e7\u00e3o sobre a Elabora\u00e7\u00e3o de uma Farmacopeia Europeia.\u201d<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31493fa elementor-widget elementor-widget-text-editor\" data-id=\"31493fa\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Ainda que os alertas sobre a possibilidade de conter azidos em IFAs tenha se iniciado no primeiro semestre de 2021, somente em setembro do mesmo ano a <\/span><b>EDQM<\/b><span style=\"font-weight: 400\"> se manifestou e <\/span><span style=\"color: #003366\"><strong><a style=\"color: #003366\" href=\"https:\/\/www.edqm.eu\/en\/news\/risk-presence-mutagenic-azido-impurities-losartan-active-substance\" target=\"_blank\" rel=\"noopener\">emitiu uma nota<\/a><\/strong><\/span><span style=\"font-weight: 400\"> informando sobre os resultados da investiga\u00e7\u00e3o que havia demonstrado que a impureza \u201cazido\u201d, identificada em IFAs pertencentes \u00e0 classe das sartanas, possu\u00eda potencial mutag\u00eanico, tendo apresentado resultado positivo no teste Ames (teste de mutagenicidade bacteriana).<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ebf349f elementor-widget elementor-widget-text-editor\" data-id=\"ebf349f\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">No \u00e2mbito internacional, existem alguns outros \u00f3rg\u00e3os de extrema relev\u00e2ncia al\u00e9m das ag\u00eancias Food and Drugs Administration (FDA) e European European Medicines Agency (EMA).\u00a0 S\u00e3o ele:<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-39f8134 elementor-widget elementor-widget-text-editor\" data-id=\"39f8134\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li style=\"font-weight: 400\"><b>Europa: <\/b><span style=\"font-weight: 400\">European Directorate for the Quality of Medicines &amp; HealthCare \u2013<\/span><b> EDQM<\/b><\/li><li style=\"font-weight: 400\"><b>Canad\u00e1:<\/b><span style=\"font-weight: 400\"> Health Canada<\/span><\/li><li style=\"font-weight: 400\"><b>Reino Unido:<\/b><span style=\"font-weight: 400\"> Medicines and Healthcare Products Regulatory Agency \u2013<\/span><b> MHRA<\/b><\/li><li style=\"font-weight: 400\"><b>Austr\u00e1lia:<\/b><span style=\"font-weight: 400\"> Therapeutic Goods Administration \u2013<\/span><b> TGA<\/b><\/li><li style=\"font-weight: 400\"><b>Cingapura:<\/b><span style=\"font-weight: 400\"> Health Sciences Authority \u2013 <\/span><b>HSA<\/b><\/li><li><b>Su\u00ed\u00e7a:<\/b><span style=\"font-weight: 400\"> Swissmedic<\/span><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e97a23 elementor-widget elementor-widget-text-editor\" data-id=\"2e97a23\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Todos eles, ap\u00f3s estarem alertas sobre os azidos, come\u00e7aram a se mover de forma a controlar esta subst\u00e2ncia nos medicamentos de seus respectivos pa\u00edses. No Brasil, ocorreu o recolhimento de alguns dos medicamentos alvos, o processo aconteceu de forma volunt\u00e1ria como forma de preven\u00e7\u00e3o por parte das empresas. A Anvisa recomenda que as empresas fa\u00e7am a avalia\u00e7\u00e3o de seus produtos para essa impureza e aguarda o envio da documenta\u00e7\u00e3o necess\u00e1ria, similar ao processo das nitrosaminas. <\/span><a href=\"https:\/\/www.gov.br\/anvisa\/pt-br\/assuntos\/fiscalizacao-e-monitoramento\/consulta-de-produtos-irregulares\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\"><span style=\"color: #003366\"><strong>Confira os produtos irregulares aqui<\/strong><\/span>.<\/span><\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-82840b3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"82840b3\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6e1856c\" data-id=\"6e1856c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cd0dd4c elementor-widget elementor-widget-heading\" data-id=\"cd0dd4c\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-medium\">Mas espere um momento, o que s\u00e3o esses azidos? <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-45cac9d elementor-widget elementor-widget-text-editor\" data-id=\"45cac9d\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Especificamente, s\u00e3o os organos azidos as impurezas encontradas em medicamentos. Eles s\u00e3o mol\u00e9culas org\u00e2nicas que cont\u00e9m em sua estrutura o grupo funcional azida (-N<\/span><span style=\"font-weight: 400\">3<\/span><span style=\"font-weight: 400\">). S\u00e3o potencialmente mutag\u00eanicos e est\u00e3o classificados na classe 3 segundo o <\/span><a href=\"https:\/\/database.ich.org\/sites\/default\/files\/M7_R1_Guideline.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\">ICH M7<\/span><\/a><span style=\"font-weight: 400\">.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4df5d93 elementor-widget elementor-widget-text-editor\" data-id=\"4df5d93\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><i><span style=\"font-weight: 400\">Nota: Classe 3: Alerta estrutural, n\u00e3o relacionada \u00e0 estrutura da subst\u00e2ncia medicamentosa; sem dados de mutagenicidade. &#8211; Controlar dentro ou abaixo dos limites aceit\u00e1veis (TTC apropriado) ou realizar ensaio de mutagenicidade bacteriana.<\/span><\/i><\/p><ul><li><i><span style=\"font-weight: 400\">Se n\u00e3o mutag\u00eanico = Classe 5<\/span><\/i><\/li><li style=\"font-weight: 400\"><i><span style=\"font-weight: 400\">Se mutag\u00eanico = Classe 2.<\/span><\/i><\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a9f89d elementor-widget elementor-widget-text-editor\" data-id=\"1a9f89d\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><i><span style=\"font-weight: 400\">Nota 2: <\/span><\/i><strong><span style=\"color: #003366\"><a style=\"color: #003366\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18573621\/\" target=\"_blank\" rel=\"noopener\"><i>TTC, do ingl\u00eas Threshold of Toxicological Concern<\/i><\/a><\/span><\/strong><i><span style=\"font-weight: 400\"><strong>.<\/strong> \u201cLimiar de Preocupa\u00e7\u00e3o Toxicol\u00f3gica\u201d, sua abordagem \u00e9 uma forma de caracteriza\u00e7\u00e3o de risco na qual as incertezas decorrentes do uso de dados de outros compostos s\u00e3o equilibradas com o baixo n\u00edvel de exposi\u00e7\u00e3o.<\/span><\/i><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-60d0078 elementor-widget elementor-widget-image\" data-id=\"60d0078\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"221\" src=\"https:\/\/insilicall.com\/wp-content\/uploads\/2022\/03\/gafr-1024x353.png\" class=\"attachment-large size-large wp-image-11066\" alt=\"grupamento azida e suas formas de resson\u00e2ncia - impurezas de azidas - organo azido, nova impureza de medicamentos\" srcset=\"https:\/\/insilicall.com\/wp-content\/uploads\/2022\/03\/gafr-1024x353.png 1024w, https:\/\/insilicall.com\/wp-content\/uploads\/2022\/03\/gafr-300x103.png 300w, https:\/\/insilicall.com\/wp-content\/uploads\/2022\/03\/gafr-768x265.png 768w, https:\/\/insilicall.com\/wp-content\/uploads\/2022\/03\/gafr-1536x529.png 1536w, https:\/\/insilicall.com\/wp-content\/uploads\/2022\/03\/gafr.png 1800w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b5eb83e elementor-widget elementor-widget-text-editor\" data-id=\"b5eb83e\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">O grupamento das azidas org\u00e2nicas consiste em 3 nitrog\u00eanios ligados (N<\/span><span style=\"font-weight: 400\">3<\/span><span style=\"font-weight: 400\">), e apresenta uma grande variedade de formas de obten\u00e7\u00e3o como, inser\u00e7\u00e3o do grupo N<\/span><span style=\"font-weight: 400\">3<\/span><span style=\"font-weight: 400\">, inser\u00e7\u00e3o de um grupo N<\/span><span style=\"font-weight: 400\">2<\/span><span style=\"font-weight: 400\">, inser\u00e7\u00e3o de um \u00e1tomo de nitrog\u00eanio, clivagem de triazinas e rearranjo de azidas. Segundo sua distribui\u00e7\u00e3o eletr\u00f4nica, ela apresenta resson\u00e2ncia, e pode ser representada pelas 3 formas exemplificadas na imagem acima (caso voc\u00ea se depare com alguma delas, j\u00e1 sabe do que se trata). S\u00e3o compostos bastante interessantes \u00e0 ind\u00fastria por sua redu\u00e7\u00e3o \u00e0 aminas, mol\u00e9culas fundamentais na forma\u00e7\u00e3o de nitrosaminas (subst\u00e2ncias potencialmente carcinog\u00eanicas e genot\u00f3xicas).<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e24af52 elementor-widget elementor-widget-heading\" data-id=\"e24af52\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-medium\">Rea\u00e7\u00e3o de forma\u00e7\u00e3o de forma simplificada.<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dd8538b elementor-widget elementor-widget-text-editor\" data-id=\"dd8538b\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Se utilizando da estrutura das sartanas, os organo azidos podem ser formados em rea\u00e7\u00e3o a um bom grupo abandonador, por meio da substitui\u00e7\u00e3o nucleof\u00edlica total da mol\u00e9cula por um N<\/span><span style=\"font-weight: 400\">3<\/span><span style=\"font-weight: 400\">-. Posi\u00e7\u00f5es reativas da mol\u00e9cula tamb\u00e9m podem dar lugar a um N<\/span><span style=\"font-weight: 400\">3<\/span><span style=\"font-weight: 400\">; por substitui\u00e7\u00e3o ou cicliza\u00e7\u00e3o. Lembrando que a rea\u00e7\u00e3o pode acontecer em apenas um s\u00edtio reativo ou dois, como acontece no caso das Losartana.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-50b4ae9 elementor-widget elementor-widget-text-editor\" data-id=\"50b4ae9\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><i><span style=\"font-weight: 400\">Nota: Grupo abandonador: Um \u00e1tomo ou grupo (carregado ou neutro) que leva consigo o par de el\u00e9trons quando substitu\u00eddo por outro grupo ou \u00e1tomo\u00a0 mais reativo.<\/span><\/i><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b408d65 elementor-widget elementor-widget-text-editor\" data-id=\"b408d65\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Partimos desse entendimento sobre a substitui\u00e7\u00e3o de um grupo abandonador por uma mol\u00e9cula de N<\/span><span style=\"font-weight: 400\">3<\/span><span style=\"font-weight: 400\">&#8211;<\/span><span style=\"font-weight: 400\">, levando (para) a forma\u00e7\u00e3o de um organo azido. Entretanto, \u00e9 necess\u00e1rio considerar cada rea\u00e7\u00e3o com seus substratos utilizados. Na rota de s\u00edntese outras impurezas podem ser formadas, a depender sempre do processo e dos componentes dispon\u00edveis.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b64d4d7 elementor-widget elementor-widget-text-editor\" data-id=\"b64d4d7\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">No caso espec\u00edfico da Losartana, por interm\u00e9dio de rea\u00e7\u00f5es espec\u00edficas, pode-se derivar dois tipos de impurezas. Sendo a Impureza 2, aquela presente nos medicamentos recolhidos.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8f96bfb elementor-widget elementor-widget-image\" data-id=\"8f96bfb\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"640\" height=\"221\" src=\"https:\/\/insilicall.com\/wp-content\/uploads\/2022\/03\/certaaaImagens-e-tabela-nitro-quim-3-1024x353.png\" class=\"attachment-large size-large wp-image-11068\" alt=\"Losartana e suas impurezas derivadas.\" srcset=\"https:\/\/insilicall.com\/wp-content\/uploads\/2022\/03\/certaaaImagens-e-tabela-nitro-quim-3-1024x353.png 1024w, https:\/\/insilicall.com\/wp-content\/uploads\/2022\/03\/certaaaImagens-e-tabela-nitro-quim-3-300x103.png 300w, https:\/\/insilicall.com\/wp-content\/uploads\/2022\/03\/certaaaImagens-e-tabela-nitro-quim-3-768x265.png 768w, https:\/\/insilicall.com\/wp-content\/uploads\/2022\/03\/certaaaImagens-e-tabela-nitro-quim-3-1536x529.png 1536w, https:\/\/insilicall.com\/wp-content\/uploads\/2022\/03\/certaaaImagens-e-tabela-nitro-quim-3.png 1800w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e4bbd12 elementor-widget elementor-widget-text-editor\" data-id=\"e4bbd12\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">\u00c9 importante salientar que a <\/span><span style=\"color: #003366\"><strong><a style=\"color: #003366\" href=\"https:\/\/www.gov.br\/anvisa\/pt-br\/assuntos\/noticias-anvisa\/2022\/comunicado-anvisa-sobre-recolhimentos-envolvendo-produtos-contendo-losartana\" target=\"_blank\" rel=\"noopener\">recomenda\u00e7\u00e3o da Anvisa<\/a><\/strong><\/span><span style=\"font-weight: 400\"> \u00e9 de que os pacientes n\u00e3o deixem de fazer uso dos medicamentos (sartanas), e que estes \u201cs\u00e3o seguros e eficazes no controle do tratamento de hipertens\u00e3o e insufici\u00eancia card\u00edaca, reduzindo significativamente o risco de derrame e infarto.\u201d<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9709d7c elementor-widget-divider--separator-type-pattern elementor-widget-divider--no-spacing elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"9709d7c\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#0c0d0e;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider .elementor-divider__element{margin:0 var(--divider-element-spacing);flex-shrink:0}.elementor-widget-divider .elementor-icon{font-size:var(--divider-icon-size)}.elementor-widget-divider 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.elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-divider\" style=\"--divider-pattern-url: url(&quot;data:image\/svg+xml,%3Csvg xmlns=&#039;http:\/\/www.w3.org\/2000\/svg&#039; preserveAspectRatio=&#039;xMidYMid meet&#039; overflow=&#039;visible&#039; height=&#039;100%&#039; viewBox=&#039;0 0 126 26&#039; fill=&#039;black&#039; stroke=&#039;none&#039;%3E%3Cpath d=&#039;M10.7,6l2.5,2.6l-4,4.3l4,5.4l-2.5,1.9l-4.5-5.2l-3.9,4.2L0.7,17L4,13.1L0,8.6l2.3-1.3l3.9,3.9L10.7,6z M23.9,6.6l4.2,4.5L32,7.2l2.3,1.3l-4,4.5l3.2,3.9L32,19.1l-3.9-3.3l-4.5,4.3l-2.5-1.9l4.4-5.1l-4.2-3.9L23.9,6.6zM73.5,6L76,8.6l-4,4.3l4,5.4l-2.5,1.9l-4.5-5.2l-3.9,4.2L63.5,17l4.1-4.7L63.5,8l2.3-1.3l4.1,3.6L73.5,6z M94,6l2.5,2.6l-4,4.3l4,5.4L94,20.1l-3.9-5l-3.9,4.2L84,17l3.2-3.9L84,8.6l2.3-1.3l3.2,3.9L94,6z M106.9,6l4.5,5.1l3.9-3.9l2.3,1.3l-4,4.5l3.2,3.9l-1.6,2.1l-3.9-4.2l-4.5,5.2l-2.5-1.9l4-5.4l-4-4.3L106.9,6z M53.1,6l2.5,2.6l-4,4.3l4,4.6l-2.5,1.9l-4.5-4.5l-3.5,4.5L43.1,17l3.2-3.9l-4-4.5l2.3-1.3l3.9,3.9L53.1,6z&#039;\/%3E%3C\/svg%3E&quot;);\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1194ccb elementor-widget elementor-widget-text-editor\" data-id=\"1194ccb\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">A forma\u00e7\u00e3o dessas impurezas n\u00e3o se aplica apenas \u00e0 classe das sartanas, ainda que tenham sido elas as primeiras investigadas e precursoras do alerta \u00e0s ag\u00eancias. Deve-se analisar minuciosamente a rota de s\u00edntese e materiais de partida dos medicamentos e cosm\u00e9ticos, e a partir da\u00ed \u00e9 que as impurezas passam a ser buscadas, in silico ou in vitro.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-72f0d7b elementor-widget elementor-widget-text-editor\" data-id=\"72f0d7b\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Assim como as nitrosaminas, o teor dessa impureza deve ser controlado para que n\u00e3o exceda o teor m\u00e1ximo permitido. Esse valor \u00e9 encontrado a partir da dosagem do medicamento, informa\u00e7\u00f5es toxicol\u00f3gicas e seu pr\u00f3prio TTC.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c71a84e elementor-widget elementor-widget-text-editor\" data-id=\"c71a84e\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Deve-se, ent\u00e3o, fazer a busca qualitativa e quantitativa (quando necess\u00e1rio) dos organo azidos e caso encontrada a impureza a n\u00edveis acima dos estabelecidos, deve-se seguir com as recomenda\u00e7\u00f5es j\u00e1 propostas anteriormente (<\/span><span style=\"color: #003366\"><strong><a style=\"color: #003366\" href=\"http:\/\/antigo.anvisa.gov.br\/documents\/10181\/6279847\/(1)Guia_50_Nitrosaminas_rev_final_para+publica%C3%A7%C3%A3o.pdf\/12af2904-e5a7-4774-9528-f4f633cac2bf\" target=\"_blank\" rel=\"noopener\">vide o Guia para o controle de nitrosaminas<\/a><\/strong><\/span><span style=\"font-weight: 400\">). A realiza\u00e7\u00e3o das altera\u00e7\u00f5es devem ser propostas e um p\u00f3s-registro deve ser realizado para regulariza\u00e7\u00e3o da nova rota.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-18216a8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"18216a8\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-70ec0f5\" data-id=\"70ec0f5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-11abd61 elementor-widget-divider--separator-type-pattern elementor-widget-divider--no-spacing elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"11abd61\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\" style=\"--divider-pattern-url: url(&quot;data:image\/svg+xml,%3Csvg xmlns=&#039;http:\/\/www.w3.org\/2000\/svg&#039; preserveAspectRatio=&#039;xMidYMid meet&#039; overflow=&#039;visible&#039; height=&#039;100%&#039; viewBox=&#039;0 0 126 26&#039; fill=&#039;black&#039; stroke=&#039;none&#039;%3E%3Cpath d=&#039;M10.7,6l2.5,2.6l-4,4.3l4,5.4l-2.5,1.9l-4.5-5.2l-3.9,4.2L0.7,17L4,13.1L0,8.6l2.3-1.3l3.9,3.9L10.7,6z M23.9,6.6l4.2,4.5L32,7.2l2.3,1.3l-4,4.5l3.2,3.9L32,19.1l-3.9-3.3l-4.5,4.3l-2.5-1.9l4.4-5.1l-4.2-3.9L23.9,6.6zM73.5,6L76,8.6l-4,4.3l4,5.4l-2.5,1.9l-4.5-5.2l-3.9,4.2L63.5,17l4.1-4.7L63.5,8l2.3-1.3l4.1,3.6L73.5,6z M94,6l2.5,2.6l-4,4.3l4,5.4L94,20.1l-3.9-5l-3.9,4.2L84,17l3.2-3.9L84,8.6l2.3-1.3l3.2,3.9L94,6z M106.9,6l4.5,5.1l3.9-3.9l2.3,1.3l-4,4.5l3.2,3.9l-1.6,2.1l-3.9-4.2l-4.5,5.2l-2.5-1.9l4-5.4l-4-4.3L106.9,6z M53.1,6l2.5,2.6l-4,4.3l4,4.6l-2.5,1.9l-4.5-4.5l-3.5,4.5L43.1,17l3.2-3.9l-4-4.5l2.3-1.3l3.9,3.9L53.1,6z&#039;\/%3E%3C\/svg%3E&quot;);\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-746a763 elementor-widget elementor-widget-text-editor\" data-id=\"746a763\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>*Autor colaborador: <a href=\"https:\/\/www.linkedin.com\/in\/celso-rodrigo-nicoleti-2a791b47\/\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #003366\">Dr. Celso R. Nicoleti<\/span><\/a><br \/><\/strong><strong>*Autora colaboradora: <span style=\"color: #003366\"><a style=\"color: #003366\" href=\"https:\/\/www.linkedin.com\/in\/luceliagrodrigues\/\" target=\"_blank\" rel=\"noopener\">Luc\u00e9lia Gomes Rodrigues<\/a><\/span><\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-c94e825 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c94e825\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f53ec7e\" data-id=\"f53ec7e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bd9865c elementor-widget-divider--separator-type-pattern elementor-widget-divider--no-spacing elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"bd9865c\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\" style=\"--divider-pattern-url: url(&quot;data:image\/svg+xml,%3Csvg xmlns=&#039;http:\/\/www.w3.org\/2000\/svg&#039; preserveAspectRatio=&#039;xMidYMid meet&#039; overflow=&#039;visible&#039; height=&#039;100%&#039; viewBox=&#039;0 0 126 26&#039; fill=&#039;black&#039; stroke=&#039;none&#039;%3E%3Cpath d=&#039;M10.7,6l2.5,2.6l-4,4.3l4,5.4l-2.5,1.9l-4.5-5.2l-3.9,4.2L0.7,17L4,13.1L0,8.6l2.3-1.3l3.9,3.9L10.7,6z M23.9,6.6l4.2,4.5L32,7.2l2.3,1.3l-4,4.5l3.2,3.9L32,19.1l-3.9-3.3l-4.5,4.3l-2.5-1.9l4.4-5.1l-4.2-3.9L23.9,6.6zM73.5,6L76,8.6l-4,4.3l4,5.4l-2.5,1.9l-4.5-5.2l-3.9,4.2L63.5,17l4.1-4.7L63.5,8l2.3-1.3l4.1,3.6L73.5,6z M94,6l2.5,2.6l-4,4.3l4,5.4L94,20.1l-3.9-5l-3.9,4.2L84,17l3.2-3.9L84,8.6l2.3-1.3l3.2,3.9L94,6z M106.9,6l4.5,5.1l3.9-3.9l2.3,1.3l-4,4.5l3.2,3.9l-1.6,2.1l-3.9-4.2l-4.5,5.2l-2.5-1.9l4-5.4l-4-4.3L106.9,6z M53.1,6l2.5,2.6l-4,4.3l4,4.6l-2.5,1.9l-4.5-4.5l-3.5,4.5L43.1,17l3.2-3.9l-4-4.5l2.3-1.3l3.9,3.9L53.1,6z&#039;\/%3E%3C\/svg%3E&quot;);\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9e5d555 elementor-headline--style-highlight elementor-widget elementor-widget-animated-headline\" data-id=\"9e5d555\" data-element_type=\"widget\" data-settings=\"{&quot;marker&quot;:&quot;double_underline&quot;,&quot;highlighted_text&quot;:&quot;InsilicAll&quot;,&quot;headline_style&quot;:&quot;highlight&quot;,&quot;loop&quot;:&quot;yes&quot;,&quot;highlight_animation_duration&quot;:1200,&quot;highlight_iteration_delay&quot;:8000,&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"animated-headline.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<link rel=\"stylesheet\" href=\"https:\/\/insilicall.com\/wp-content\/plugins\/elementor-pro\/assets\/css\/widget-animated-headline.min.css\">\t\t<h3 class=\"elementor-headline\">\n\t\t\t\t\t<span class=\"elementor-headline-plain-text elementor-headline-text-wrapper\">Sobre a<\/span>\n\t\t\t\t<span class=\"elementor-headline-dynamic-wrapper elementor-headline-text-wrapper\">\n\t\t\t\t\t<span class=\"elementor-headline-dynamic-text elementor-headline-text-active\">InsilicAll<\/span>\n\t\t\t\t<\/span>\n\t\t\t\t<\/h3>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-db58585 elementor-widget elementor-widget-text-editor\" data-id=\"db58585\" data-element_type=\"widget\" data-settings=\"{&quot;ultimate_floating_fx_translate_y&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span style=\"font-weight: 400\">Somos a primeira empresa LATAM que empodera a ind\u00fastria farmac\u00eautica em seus desafios de drug discovery e em toxicologia regulat\u00f3ria aplicando IA e automa\u00e7\u00e3o biol\u00f3gica. Com nosso modelo SaaS aumentamos a taxa de sucesso de nossos clientes levando medicamentos inovadores para os pacientes de forma mais r\u00e1pida e garantindo a seguran\u00e7a toxicol\u00f3gica de sua produ\u00e7\u00e3o. Nossa miss\u00e3o de entregar a melhor tecnologia com o menor impacto (ESG) nos permite garantir para nossos clientes a otimiza\u00e7\u00e3o de tempo, custos e experimenta\u00e7\u00e3o animal em seus processos.<\/span><\/p><p><span style=\"font-weight: 400\">Trabalhamos para aumentar a taxa de sucesso em levar medicamentos inovadores para as necessidades dos pacientes, diminuindo o cronograma, os custos e o tempo para que um novo produto chegue \u00e0 sociedade. Para isso, nossa empresa integra IA, computa\u00e7\u00e3o e automa\u00e7\u00e3o biol\u00f3gica para acelerar o design de novas mol\u00e9culas e prote\u00ednas terap\u00eauticas.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Nitrosaminas n\u00e3o os \u00fanicos contaminantes de IFAs, desde 2021 a classe dos azidos (organo azidos) tem sido investigada por ag\u00eancias [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":11107,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_lock_modified_date":false,"footnotes":""},"categories":[110,79],"tags":[78,186,185,187,155,183,184,124,112,182,162],"class_list":["post-11065","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-atualidades","category-noticias","tag-anvisa","tag-azidas","tag-genotoxico","tag-grupo-azida","tag-impureza","tag-impurezas","tag-mutagenico","tag-nitrosamina","tag-nitrosaminas","tag-organo-azidos","tag-risco","no-social-count","single-post-item mb40"],"_links":{"self":[{"href":"https:\/\/insilicall.com\/wp-json\/wp\/v2\/posts\/11065"}],"collection":[{"href":"https:\/\/insilicall.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/insilicall.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/insilicall.com\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/insilicall.com\/wp-json\/wp\/v2\/comments?post=11065"}],"version-history":[{"count":39,"href":"https:\/\/insilicall.com\/wp-json\/wp\/v2\/posts\/11065\/revisions"}],"predecessor-version":[{"id":15299,"href":"https:\/\/insilicall.com\/wp-json\/wp\/v2\/posts\/11065\/revisions\/15299"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/insilicall.com\/wp-json\/wp\/v2\/media\/11107"}],"wp:attachment":[{"href":"https:\/\/insilicall.com\/wp-json\/wp\/v2\/media?parent=11065"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/insilicall.com\/wp-json\/wp\/v2\/categories?post=11065"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/insilicall.com\/wp-json\/wp\/v2\/tags?post=11065"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}